| abstract |
The invention relates to a preparation method of an eribulin intermediate. Specifically, the present invention relates to a compound as shown in formula IV, wherein, R 1 is a hydroxyl protecting group, preferably (C 1-10 alkyl or aryl) 3 silyl, more preferably TBDPS; R 2 A hydroxyl protecting group, preferably benzyl or (C 1-10 alkyl or aryl) 3 silyl, more preferably benzyl or TBS. The present invention also particularly relates to a preparation method of the compound represented by formula IV, which has the advantages of mild reaction conditions, simple operation, low synthesis cost, etc., and is suitable for large-scale production. . |