http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108948040-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2018-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108948040-B |
| titleOfInvention | Gilmaxane type sesquiterpene compound extracted from herba Centellae and application thereof |
| abstract | A germacrane type sesquiterpene Carpescernolides A compound extracted from herba Centellae is obtained by separating and extracting whole plant of herba Centellae with structural formula of (І), and its preparation method comprises ethanol extraction, extract concentration, silica gel column chromatography, gradient elution, gel column chromatography, and semi-preparative high performance liquid chromatography purification. The invention discloses a gemmarane type sesquiterpene Carpeschernolides A compound which is extracted and separated from Bidens pinnatifida (Bidens pinnatifida) of Anshuzhen in Guizhou for the first time, the structural formula of the compound is determined, the compound has a treatment effect on cells of human liver cancer cells SMMC-7721, can induce apoptosis of the SMMC-7721 cells, promotes generation and accumulation of endogenous ROS in a dose-dependent manner, inhibits migration of tumor cells, inhibits formation of tumor cell clone, can be applied to preparation of a medicament for treating liver cancer, and can be used as a leading compound of the medicament for treating liver cancer. |
| priorityDate | 2018-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.