http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108947993-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-10 |
| filingDate | 2018-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108947993-B |
| titleOfInvention | Method for green and efficient synthesis of azilsartan in water phase |
| abstract | The invention relates to a method for green and efficient synthesis of azilsartan in a water phase, and belongs to the field of medicines. According to the invention, water is used as a solvent, 1- [ (2' - (hydroxycarbamimidoyl) [1, 1-biphenyl ] -4-yl) methyl ] -2-ethoxy-1H-benzimidazole-7-methyl formate and a carbonylation reagent are used as starting materials, and the azilsartan is synthesized by one-step reaction under the action of alkali, so that the three reactions of esterification, cyclization and hydrolysis are simplified into one step, the reaction time is greatly shortened, the reaction yield is improved, and the product purity is high. The water is used as a reaction solvent, so that the defects of high toxicity, unsafe production and the like of an organic solvent in the prior art are overcome, and a simple and effective green synthesis method is provided for the synthesis of the azilsartan. |
| priorityDate | 2018-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.