http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108939082-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F220-585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F220-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F222-102 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F230-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F222-1006 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F222-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F230-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2018-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108939082-B |
| titleOfInvention | Preparation method of POSS (polyhedral oligomeric silsesquioxane) and MCM-41-MPS (MCM-41-MPS) -doped capecitabine molecularly imprinted sustained and controlled release material |
| abstract | The invention relates to a preparation method of a capecitabine molecularly imprinted sustained and controlled release material integrating POSS (polyhedral oligomeric silsesquioxane) and MCM-41-MPS (mesoporous crystalline silicon) -doped, in particular to a preparation method and performance evaluation of a capecitabine molecularly imprinted sustained and controlled release material doped with polyhedral oligomeric silsesquioxane and mesoporous molecular sieve MCM-41. The result shows that the simultaneous existence of POSS and MCM-41-MPS can obviously improve the selective recognition capability and the adsorption performance of the molecularly imprinted polymer, generate better imprinting effect and have certain influence on the specific surface area, the pore size distribution and the like of the polymer. The hybrid MIP is used as a carrier material of capecitabine, and in-vitro and in-vivo drug release experiments prove that the drug release time of the optimal formula is obviously prolonged and the relative bioavailability (F is 173.4 percent) is obviously improved, so the hybrid MIP has great research significance and practical value when being used as a sustained-release material of capecitabine. |
| priorityDate | 2018-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.