http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108938560-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_626455230c5db3ed72d855c265f39331 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-12 |
| filingDate | 2017-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9e3541f7807980b7fb20863cb75a4f0 |
| publicationDate | 2018-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108938560-A |
| titleOfInvention | A kind of preparation method of Nalmefene hydrochloride injection and its Nalmefene hydrochloride injection obtained |
| abstract | The invention discloses a kind of preparation methods of Nalmefene hydrochloride injection, routinely method is when preparing Nalmefene hydrochloride injection, a certain amount of citric acid or citrate auxiliary material are added in the formulation, additional amount is that citric acid or citrate 5-15g are added in its every liter injection.The auxiliary material that recipe quantity will be first taken when preparation, is dissolved in water for injection, and adds active carbon stirring and adsorbing, filters impurity elimination；Then under nitrogen protection, the nalmefene hydrochloride of recipe quantity is added, after completely dissolution, with water constant volume to designated volume, adjusts pH value to 3.5-4.5, dispenses, nitrogen charging, seal after finally being filtered with filter, sterilize.The method of the present invention can be obviously prolonged Nalmefene hydrochloride injection validity period, and using specific citric acid pH stable agent, stability is good, and sample appearance character, pH value, active constituent content and related substance etc. are more stable, ensure that the safety of medication. |
| priorityDate | 2017-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.