http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108912284-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F289-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F289-00 |
| filingDate | 2018-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108912284-B |
| titleOfInvention | Acrylic acid grafted natural collagen with fibrosis performance and preparation method thereof |
| abstract | The invention discloses acrylic acid grafted natural collagen with fibrosis performance and a preparation method thereof. The preparation method comprises the following steps: (1) dissolving natural collagen with an acidic solvent to obtain a natural collagen solution; (2) performing primary dialysis on the natural collagen solution obtained in the step (1) by using a phosphate buffer solution to remove acetic acid molecules; (3) dropwise adding a phosphate buffer solution dissolved with N-hydroxysuccinimide acrylate or acrylic anhydride into the solution obtained in the step (2), and reacting after uniformly mixing; (4) and (4) dialyzing the solution reacted in the step (3) for the second time, and freeze-drying to obtain the acrylic acid grafted natural collagen with the fibrosis performance. The invention realizes the acrylic acid covalent bond grafting of the natural collagen by simple and mild reaction conditions; and regulating and controlling the grafting rate of the graft modified natural collagen to obtain the graft modified natural collagen with the fibrosis capability. |
| priorityDate | 2018-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.