http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108912194-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 2018-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108912194-B |
| titleOfInvention | A kind of preparation method of 21-hydroxy-1,4,9(11),16-pregnatetraene-3,20-dione-21-acetate |
| abstract | The present invention provides a kind of preparation methods of 21-hydroxy-1,4,9(11),16-pregnatetraene-3,20-dione-21-acetate.This method are as follows: under inert gas protection; by the pregnant steroid -1 of raw material 17- alkynes; 4; 9 (11)-triolefin -3- ketone -17- hydroxacetic acid ester is under the action of catalyst acetic acid palladium and oxidant 1,4-benzoquinone; reaction generates intermediate 18- monohydric pregnant -1 in organic solvent; 4; 9 (11), 17- tetraene -3,19- diketone -18- acetate; again with 1; 11 carbon -7- alkene of 8- diazabicylo handles to obtain 21-hydroxy-1,4,9(11),16-pregnatetraene-3,20-dione-21-acetate (21- monohydric pregnant-Isosorbide-5-Nitrae, 9 (11); 16- tetraene -3,20- diketone -21- acetate).The method of the present invention avoids corroding less equipment, while improving the purity of product using palladium chloride, copper chloride and oxygen.It is easy to operate with safe and efficient, the advantages that being suitable for industrialized production, there is biggish application value. |
| priorityDate | 2018-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.