| abstract |
The invention discloses a preparation method of dexchloroglutamine, which comprises: mixing N-tert-butoxycarbonyl-D-glutamic acid-5-benzyl ester and N-(3-methoxypropyl)-pentylamine After acylation by acid anhydride method, the tert-butoxycarbonyl group is removed to obtain Then react with 3,4-dichlorobenzoyl chloride to generate Finally debenzylation, that is, to obtain dexloglutamine. Compared with the prior art, the method of the invention has simpler operation and higher yield. |