| abstract |
Dynamic electrostatic deposition composite natural material bionic porous microcarrier and its preparation method, the invention relates to the technical field of biomedical materials or biocomposite materials, and discloses a method that can be used for human soft and hard tissue culture, tissue engineering micro-tissue construction, and human tissue repair , cell expansion, natural material biomimetic porous microcarrier in the field of drug release and its preparation method. Natural materials include chitosan, nanocellulose, animal protein, vegetable protein, polyamino acids and polypeptides. The nanocellulose is deflocculated, the protein is dissolved, centrifuged, and precipitated at low temperature, and the bionic porous microcarrier is prepared by dynamic electrostatic deposition. The beneficial effect of the present invention is: by simulating the composition and structure of the extracellular matrix, the bionic porous microcarrier is prepared by in-situ dynamic electrostatic deposition, so that it not only has good biocompatibility, good mechanical properties, but also has the ability to promote cell activity. ability. Moreover, no cross-linking agent is used in the process of preparing the bionic porous microcarrier in the present invention, so as to avoid the cytotoxicity caused by the residual cross-linking agent. |