| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_86c73dadc85d15838e62744bf71dfb42 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1044
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1007 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0215
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0021 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-037
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate |
2018-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_410b2c27bfa3c6a0e93080354d34b787
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fceb332d39106334aa447b9d049d8d7a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d18df41a0d4c5535cc82b48429d4f02a |
| publicationDate |
2018-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-108893106-A |
| titleOfInvention |
Fluorescent probe for detecting high-concentration gamma-glutamyl transpeptidase and preparation method thereof |
| abstract |
The invention provides a fluorescent probe for detecting high-concentration γ-glutamyl transpeptidase, which solves the problem of selective response to abnormally high-concentration γ-glutamyl transpeptidase in vivo. The fluorescent probe of the present invention begins to produce obvious fluorescence changes after the γ-glutamyl transpeptidase is higher than the normal concentration of the human body. As the concentration of the γ-glutamyl transpeptidase increases, the fluorescent probe solution of the present invention produces Large fluorescence enhancement and pronounced color change. At the same time, after the fluorescent probe of the present invention reacts with γ-glutamyl transpeptidase, the permeability of the cell membrane is greatly enhanced, and when applied to cell imaging, it can selectively image high-expression γ-glutamyl transpeptidase Enzymatic properties of ovarian cancer cells. The synthesis process of the invention is simple and easy, the raw materials are cheap and easy to obtain, the preparation cost is low, and it is easy to popularize. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110862818-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110862818-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113637048-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113637048-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111548790-A |
| priorityDate |
2018-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |