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filingDate 2018-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-108888804-B
titleOfInvention Soft tissue repair material and preparation method thereof
abstract The invention relates to a soft tissue repair material and a preparation method thereof, belonging to the technical field of biomedical material processing. The preparation method provided by the invention comprises the following steps: 1) removing small intestinal mucosa, muscular layer and serous membrane on small intestinal tissue of mammal, and washing for 3-5 times with antibiotic-containing sterile buffer solution to obtain washed small intestinal submucosa tissue; 2) cutting into sections, cutting open along the midline, and flattening to obtain pretreated small intestine submucosa tissue; 3) placing the mixture in a sterile buffer solution containing a surfactant and nuclease, and carrying out oscillation treatment at 37 ℃ for 1-4 h to obtain acellular small intestine submucosa tissues; 4) oscillating, cleaning, cutting and drying to obtain a dried central matrix membrane; 5) and (5) performing irradiation sterilization to obtain the soft tissue repair material. The preparation method can obtain the safe and effective soft tissue repair material with good bioactivity and biocompatibility.
priorityDate 2018-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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