| abstract |
The invention belongs to the new applications of the anti-myocardial hypertrophy of greater plantain glycosides, and in particular to greater plantain glycosides is preparing the application in anti-myocardial hypertrophy drug.The present invention uses isoprel inducing mouse animal cardiac muscle hypertrophy model and H9c2 cardiac myocyte hypertrophy model, the greater plantain glycosides for giving various concentration simultaneously is intervened, and by ultrasound Evaluation mouse heart function, weighs mouse heart weight, left ventricular mass evaluates mouse cardiac muscle hypertrophy degreeļ¼H9c2 cardiomyocyte surface area is observed using fluorescent staining, the results showed that greater plantain glycosides has protective effect to the mouse cardiac muscle hypertrophy that isoprel induces, inhibited to the H9c2 cardiac myocyte hypertrophy of isoprel induction.Being expected to exploitation is anti-myocardial hypertrophy medicinal application in clinic. |