http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108888624-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e19f4be0158b0f34a8865653cb54fc4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-585 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 |
| filingDate | 2018-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a765cdbc0d801a58d966d0854ee8ef9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a2d55ff2497eeb1783919bf18a2da24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f7c86dadf008982dbbcfd619e87ddf5 |
| publicationDate | 2018-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108888624-A |
| titleOfInvention | Application of Triptolide and Its Derivatives as Natural Agonists of Human Pregnane X Receptor |
| abstract | The present invention verifies for the first time that triptolide, the main active ingredient in the traditional Chinese medicine triptolide, and its derivatives can efficiently stimulate human pregnane X receptors, and promote the expression of important target genes such as CYP3A4 and MDR1 involved in metabolism downstream. The invention discloses that triptolide and its derivatives can be used as high-efficiency hPXR agonists, which can be used as the basis for the study of PXR agonist mechanism and the study of exogenous substance metabolism, and can be used in the clinical treatment of various diseases including metabolic diseases. treatment is possible. |
| priorityDate | 2018-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102786576-A |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID468101510 |
Total number of triples: 19.