http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108884168-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fcaed31afee960c63f0d21e133fab13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_73e0d5808f34f512649e277bd216a344 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4724 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2851 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate | 2017-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e6101ab02f3d70bb7954713eddd08d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f82900aec4c7e02d50646f1db5087ba7 |
| publicationDate | 2018-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108884168-A |
| titleOfInvention | Antibodies and their related molecules and uses |
| abstract | The present invention relates to an isolated antibody that selectively binds CLEC14A, wherein said antibody (a) comprises at least one heavy chain variable region comprising 3 CDRs and at least one light chain variable region comprising 3 CDRs, wherein said The heavy chain variable region comprises: (i) variable heavy (VH) CDR1, which has the amino acid sequence of SEQ ID NO.105, preferably SEQ ID NO: 2 or 42; (ii) VH CDR2, which has the amino acid sequence of SEQ ID NO .106, preferably SEQ ID NO:3 or 43; and/or (iii) VH CDR3, which has the amino acid sequence SEQ ID NO.107, preferably SEQ ID NO:4 or 44; and/or wherein said light chain is variable The region comprises: (iv) variable light (VL) CDR1, which has the amino acid sequence of SEQ ID NO.108, preferably SEQ ID NO:6 or 46; (v) VL CDR2, which has the amino acid sequence of SEQ ID NO.109, preferably SEQ ID NO:7 or 47; and/or (vi) VL CDR3, it has aminoacid sequence SEQ ID NO.110, preferably SEQ ID NO:8 or 48; Or (b) comprises at least one heavy chain comprising 3 CDRs Variable region and at least one light chain variable region comprising 3 CDRs, wherein the heavy chain variable region comprises: (i) variable heavy (VH) CDR1 having the amino acid sequence of SEQ ID NO: 22; (ii ) VH CDR2, which has the amino acid sequence of SEQ ID NO:23; and/or (iii) VH CDR3, which has the amino acid sequence of SEQ ID NO:24; and/or wherein said light chain variable region comprises: (iv) may Lightened (VL) CDR1, which has the amino acid sequence of SEQ ID NO: 26; (v) VL CDR2, which has the amino acid sequence of SEQ ID NO: 27; and/or (vi) VL CDR3, which has the amino acid sequence of SEQ ID NO: 28; or (c) is an antibody that competes with antibody (a) or (b) for binding to CLEC14A. The present invention also provides chimeric antigen receptors, nucleic acid molecules encoding antibodies or chimeric antigen receptors of the present invention, vectors, cells and methods/applications of antibodies and chimeric antigen receptors. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113024672-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114573694-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114573694-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113024672-A |
| priorityDate | 2016-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1356.