| abstract |
The invention discloses a separation matrix for purifying biological macromolecules, comprising a plurality of particles (1) having a core region (2) and a shell region (3), wherein: a) the shell region is accessible to the target biomacromolecule; b) the core region is less accessible to the target biomacromolecule than the shell region; and c) the core region comprises a graft polymer comprising residues of at least one polymerizable monomer. |