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filingDate 2018-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-108872418-B
titleOfInvention Liquid chromatography mass spectrometry method and liquid chromatography mass spectrometry device
abstract Liquid chromatography mass spectrometry method and liquid chromatography mass spectrometry device. [Problem] When a sample containing various compounds is analyzed by LC/MS, the ionization efficiency of each compound is improved and the detection sensitivity is improved. [Solution] In the post-column addition section 16, the additive liquid feeding pumps 164A, 164B suck and supply different kinds of additives A and B from the containers 163A, 163B, respectively, and mix them into the tee joints 162, 161. in the eluent. The combination of additives is preferably a combination of DMSO, which can obtain the aggregation effect in a charged state, and 2-propanol, which has the effect of promoting the miniaturization and vaporization of droplets. By mixing these two additives at an appropriate flow ratio according to a predetermined flow program and mixing them into the eluent, the ionization efficiency when the eluent is charged and sprayed from the ESI sprayer 21 and ionized can be obtained. It is close to the optimum state for each compound. Thereby, the detection sensitivity is also improved as compared with the past.
priorityDate 2017-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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