http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108865968-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-405 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 |
| filingDate | 2018-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108865968-B |
| titleOfInvention | Method for regulating and controlling exosome release and medical application thereof |
| abstract | Provides a method for regulating and controlling the release of exosome and the medical application of the exosome as the regulation and control of the release of exosome, and promotes the release of exosome by inhibiting the activity of rapamycin target protein mTORC 1. Inhibition of mTORC1 activation by rapamycin increases exosome release. The release of exosomes is promoted by depriving nutrients, growth factors and dietary restrictions inhibiting the activity of mTORC 1. mTORC1 regulates the release of exosomes through Rab 27A-dependent mechanisms. mTOR is associated with Rab27A and interaction between Rab27A and mTOR is enhanced by rapamycin treatment. The release of exosomes, while concomitant with autophagy, is influenced by changes in nutrient and growth factor conditions. The release of exosomes releases the cell contents out of the cell by fusion with the plasma membrane, resulting in the loss of cell contents. The invention can regulate and control the release of exosome and provides a feasible scheme for regulating and controlling the medical application of exosome release. |
| priorityDate | 2018-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.