http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108864165-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-0812 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-0827 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-10 |
| filingDate | 2018-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108864165-B |
| titleOfInvention | Flusilazole and synthesis method thereof |
| abstract | The invention discloses flusilazole and a synthesis method thereof, and the method comprises the following steps: putting magnesium chips into a Grignard reaction kettle, adding an organic solvent, uniformly stirring, cooling, adding bromobenzene difluoride at one time, mixing and stirring, dropwise adding bromobenzene difluoride, carrying out heat preservation reaction, cooling and storing to obtain a bromobenzene parafluorobromide Grignard reagent; heating a bromofluorobenzene Grignard reagent, dropwise adding methyl chloromethyl dichlorosilane, preserving heat, and recovering an organic solvent under negative pressure to obtain a flusilazole intermediate, magnesium bromide and magnesium chloride; adding DMF, stirring, cooling, centrifuging, and removing magnesium bromide and magnesium chloride to obtain DMF mother liquor; dissolving triazole sodium salt in formamide, adding DMF mother liquor, reacting, recovering DMF under negative pressure, vacuum distilling, and cooling to obtain the final product. The content of flusilazole is more than or equal to 95.0%, the yield is 80-90%, the synthesis method is mild in reaction conditions, safe to operate, low in equipment requirement, low in cost, free of waste water generation, easy to operate and implement, and suitable for large-scale production of enterprises. |
| priorityDate | 2018-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.