| abstract |
The invention discloses an oridonin derivative represented by the following general formula (1), an enantiomer, a diastereoisomer, a racemate and a mixture thereof, and pharmaceutically acceptable salts, crystal hydrates and solvates thereof, and a preparation method and application thereof. The oridonin derivative represented by the following general formula (1) has good water solubility and higher bioavailability. In vitro biological experiments prove that the oridonin derivative has higher anti-tumor activity and good effect on autoimmune diseases. |