http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108864038-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a6f422b091ba12ea61d4adbf1b0e8e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-38 |
| filingDate | 2018-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f7869a709d59fd26ac8fd5d58b778d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_407977ed37696f1eb9753fe9d4c6217e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_557a963186a831cbbed4b7aa01a24752 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4acf131e262b72b4995f578f52a9af45 |
| publicationDate | 2018-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108864038-A |
| titleOfInvention | 3-amido-N-arylbenzamide compounds and their preparation and application |
| abstract | The present invention provides 3-amido-N-arylbenzamide compounds and pharmaceutically acceptable salts thereof, adopting a converging synthetic route to divide the synthesis of the compound into different synthetic blocks, which can be rapidly prepared in batches through docking and combination target compound. It has been proved by experiments that the compounds provided by the present invention can significantly prolong the seizure latency induced by pentylenetetrazol, reduce the grade of seizures and mortality; Raise the onset threshold of intractable epilepsy; and there is no obvious toxic side effect, which shows that it can alleviate or control epilepsy, and even has a certain therapeutic effect on intractable epilepsy that is ineffective in traditional drug treatment, and can be used in the preparation of antiepileptic drugs. application. The raw materials required for the synthesis of the compound of the invention are easily available, the operation is simple and the process is highly scalable, suitable for industrial production, and a new medicine is provided for the treatment of epilepsy. The structure of general formula I: |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113717133-A |
| priorityDate | 2018-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.