http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108863923-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 |
| filingDate | 2018-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108863923-B |
| titleOfInvention | Pyridone derivative and preparation method and application thereof |
| abstract | The invention discloses a pyridone derivative, a preparation method and application thereof, wherein the pyridone derivative is mainly prepared from R 1 ，R 2 ，R 3 Structural modifications of these three substituents are made, wherein R 1 The modification of (A) is mainly carried out by allyl, isopentenyl, geranyl, p-fluorobenzyl and the like; r 2 The modification of (a) is mainly by hydroxyethyl, hydroxypropyl, aminoethyl, aminopropyl, etc.; r 3 The modification (c) is mainly focused on ethers with certain structural features. The pyridone derivative has obvious inhibition effect on pancreatic cancer cells PANC-1 in a poor nutrition state, and has no influence on the cells in a normal nutrition state (no cytotoxicity is suggested). The preparation method of the pyridone derivative firstly synthesizes basic parent nucleus bicyclo [3.3.1]Nonanone is subjected to rearrangement reaction with a series of alcohol amines or diamines under the catalysis of toluenesulfonic acid to prepare para-pancreasThe pyridone derivative has obvious cancer inhibiting effect and high practicability. |
| priorityDate | 2018-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.