| abstract |
The present invention relates to a kind of methods that application simulation mobile bed chromatic prepares gamma-thujaplicin, generate cyclopentadienyl potassium by cyclopentadiene and potassium hydroxide, then react with isopropyl bromide, heat under the conditions of strong base-weak acid salt and 2- isopropylcyclopentadiene is made；2- isopropylcyclopentadiene ketenes addition product is made in the reaction product of dichloroacetyl chloride and triethylamine and 2- isopropylcyclopentadiene addition, then carries out the crude product of ring expansion synthesis gamma-thujaplicin；The crude product of application simulation mobile bed chromatic system separation gamma-thujaplicin prepares gamma-thujaplicin, and application simulation moving bed purifies gamma-thujaplicin, and gamma-thujaplicin gross production rate is greater than 60.0%, and purity is greater than 97.0%.The present invention has the advantages that concise in technology, reaction condition are easy, at low cost, yield is high, meet environmental requirement. |