http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108836552-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc2eb439ed5dc5224878cc7e1f9cbc9d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61D1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61D1-00 |
| filingDate | 2018-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6feb41ef503f0aba986ab79c4b7192ad |
| publicationDate | 2018-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108836552-A |
| titleOfInvention | A kind of chronic thromboembolic Rats of Pulmonary Hypertension model and its construction method |
| abstract | The invention belongs to the new varieties technical fields of vertebrate, disclose a kind of chronic thromboembolic Rats of Pulmonary Hypertension model and its construction method, 10% chloral hydrate anesthesia is injected intraperitoneally, under aseptic condition, through left jugular vein, the 1.5mL physiological saline containing tranexamic acid of about 32 ± 5 autologous blood clots emboluses will be mixed with the speed embolism pulmonary artery of 0.5ml/min, slowly stirring position in embolic processes enters greater amount of embolus in rat pulmonary circulation；Visible rat cyanosis, accelerated breathing after embolism；It the 4th day after embolism, in kind carries out second, third secondary embolism within the 11st day, observes 5 weeks altogether.The CTEPH model that the present invention establishes is using autologous rat thrombus as embolic infarction pulmonary artery, by the pro-inflammatory effect of carrageenan, allow autologous blood clots vascular embolization prolonged as far as possible, the entire pathophysiological process of the secondary CTEPH of real model Clinical CT EPH patient's pulmonary embolism. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2723360-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115362987-A |
| priorityDate | 2018-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.