http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108823193-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70 |
| filingDate | 2018-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108823193-B |
| titleOfInvention | Efficient streptococcus pneumoniae chimeric lyase, and mutant and application thereof |
| abstract | The invention relates to the technical field of genetic engineering, in particular to a high-efficiency streptococcus pneumoniae chimeric lyase, a mutant and an application thereof. The invention adopts a gene splicing means to construct a brand-new chimeric lyase ClyJ, and constructs mutants ClyJ-1, ClyJ-2 and ClyJ-3 thereof by means of gene fragment insertion and deletion. The ClyJ and the mutant thereof have good stability and can effectively kill streptococcus pneumoniae in vitro and in vivo; ClyJ and the mutant thereof can be well expressed in Escherichia coli BL21(DE3), and the high-efficiency cleavage activity of the ClyJ on Streptococcus pneumoniae suggests that the ClyJ has the potential capability of preventing and treating Streptococcus pneumoniae infection. Therefore, the ClyJ and the mutant thereof can be used independently or used as additives to be compatible with reagents and solutions in different forms, are used for controlling streptococcus pneumoniae and treating infection caused by the streptococcus pneumoniae, and have wide application prospect. |
| priorityDate | 2018-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 320.