| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6a02757a65a91dff318c09e775176b0d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_557e257f7cfcfb21577689883be97322 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-067
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-067 |
| filingDate |
2018-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_249d2de5357f54a770077981a567dc62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e15a68f2f7ebb8bc3888e033fa18f649
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e9e6a3895d4106dc8bf14420fbe45ec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_467e2bea934f9f1ee28ade8a41d9430b |
| publicationDate |
2018-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-108822172-A |
| titleOfInvention |
Novel preparation method of nucleoside modified substance 5'-DMTr-2'-EOE-thymidine |
| abstract |
The present invention relates to a novel preparation method of nucleoside modifier 5'-DMTr-2'-EOE-thymidine. The method of the present invention uses the boronic acid ester modified by the specific target group as the source of the alkylated group of the sugar ring hydroxyl group, and uses cesium carbonate as a catalyst to react with the dehydrothymidine protected by 5'-DMTr-protected, high Yield, highly selective generation of target product 5'-DMTr-2'-EOE-thymidine. The method of the invention can easily and economically synthesize 5'-DMTr-2'-EOE-thymidine in large quantities. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109456376-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109456376-B |
| priorityDate |
2018-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |