http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108822048-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_75cd60bddbf9fabc2004208c1fb315de |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-38 |
| filingDate | 2018-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_740c5084687d0e0d75b6a3236419dddb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02f2a4eeea0b2684115a1205b2161250 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e571036d75e693a7558242a5a3ee43b5 |
| publicationDate | 2018-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108822048-A |
| titleOfInvention | Synthesis of 4-(4-ethyl-4,7-diazaspiro[3,3]octyl)-2-nitroaniline |
| abstract | The invention discloses a synthesis process of 4-(4-ethyl-4,7 diazaspiro[3,3]octyl)-2-nitroaniline. The specific process is as follows: the first step: using 2-Piperazinone and its 4-position nitrogen-protected derivative react with ethyl bromide under basic conditions to obtain compound 1; the second step: react compound 1 with a titanium catalyst to obtain compound 2; the third step: compound 2 Deprotection produces free base 1-ethyl-2-cyclopropyl-piperazine or its hydrochloride; the fourth step: 1-ethyl-2-cyclopropyl-piperazine or its hydrochloride is carried out with compound 3 Reaction to obtain compound 4; the fifth step: compound 4 is deprotected to obtain the product 4-(4-ethyl-4,7 diazaspiro[3,3]octyl)-2-nitroaniline. The synthesis condition of the synthesis process of the invention is simple, the raw materials used are cheap, and the selection of the deprotecting agent can not only reduce the formation of by-products, but also increase the yield of the product, so that the yield can reach as high as 80%. |
| priorityDate | 2018-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 157.