| abstract |
It is controllably loaded the present invention provides a kind of drug and the bio-medical coating material of long-acting slow-release and preparation method thereof, preparation process are as follows: polish base material, cleaning, it is dry, then (negatively charged layers) are immersed in dopamine solution, then the polyamino large biological molecule (positively charged) modified with catechol, electronegative macromolecular solution (negatively charged), load three kind components of the micella (negatively charged) as LBL self-assembly of a variety of drugs, pass through LBL self-assembly method prepares coating modified material in the processed substrate of dopamine using three of the above component, the repeatable multiple assembled layers of coating, realize that a variety of drug molecules are a large amount of and orderly to be fixed on self-assembled coating, and then realize the controllable sustained release of drug. |