| abstract |
The invention belongs to the field of medicines or health care products, and in particular relates to the application of C21 steroids of Cyperus saponica in the preparation of IDO inhibitors. The present invention finds through research that the inhibitory activity of bariclin A, baricacidin F, baricacidin U and baricacidin T on intracellular IDO is better than that of the positive control drug 1-methyl tryptophan (1-MT ) has significant IDO inhibitory activity, and can be used to treat cancer, Alzheimer's disease, autoimmune diseases, ankylosing spondylitis, bacterial infections, cataracts, mood disorders, and depression or anxiety disorders. |