http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108780096-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0867 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2200-0652 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-502761 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-92 |
| filingDate | 2016-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108780096-B |
| titleOfInvention | Methods for analyzing the activity of ion channels |
| abstract | The present invention relates to a method for analyzing the activity of an ion channel (3), said method comprising the steps of: (i) providing a first droplet of an aqueous solution AS1 in a hydrophobic medium ( 1 ), said aqueous solution AS1 containing a concentration Ion I of q, where c 1 ≥ 0, where droplet D 1 is surrounded by a monolayer of amphiphilic molecules (2), (ii) provides a second droplet D of aqueous solution AS 2 in said hydrophobic medium (1) 2 , the aqueous solution AS 2 contains ions I at a concentration c 2 , where c 1 ≥ 0 and c 2 ≠ c 1 , wherein the droplet D 2 is surrounded by a monolayer of amphiphilic molecules (2), the two The philophile (2) further comprises the ion channel to be analysed (3), (iii) the amphiphilic molecule ( 2 ) which contacts the first droplet D1 and the second droplet D2 to form a bilayer in the contact area, Wherein the amphiphilic molecule of the bilayer (2) further contains the ion channel to be analyzed (3), measuring the radius of the two droplets at the time of contact called the initial state, and (iv) maintaining the first droplet D1 and the first The two droplets D2 are contacted until equilibrium is reached, and the radii of the two contacted droplets are measured or the number of droplets produced at equilibrium called the equilibrium state, where at least one droplet is in its initial state and its equilibrium The ion channel (3) is inactive when the radius difference between states is at least 10% or when only one droplet is obtained at equilibrium. |
| priorityDate | 2015-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.