| abstract |
The invention discloses a urea derivative and its application in preventing and treating inflammation. Wherein: R 1 , R 2 , R 3 are each independently selected from H, F or CH 3 . From the in vitro activity measurement results, it can be seen that the compound of the present invention has 5-lipoxygenase inhibitory activity and prostaglandin E synthase inhibitory activity, and can be used as a drug for treating inflammation to carry out more in-depth and extensive research. The inflammation can be gynecological inflammation , hepatitis, myocarditis, encephalitis, nephritis, pneumonia, bronchitis, pharyngitis, periodontitis, gastritis, enteritis, etc. |