http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108774190-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D267-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D267-14 |
| filingDate | 2018-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108774190-B |
| titleOfInvention | Method for multi-step synthesis of 2-benzyl-1, 5-dihydrobenzo [ e ] [1,4] oxazepine |
| abstract | The invention discloses a method for synthesizing 2-benzyl-1, 5-dihydrobenzo [ e ] [1,4] oxazepine in multiple steps, and belongs to the technical field of organic synthesis. The method comprises the steps of forming ether by adopting o-nitrobenzyl alcohol and propargyl bromide or propargyl alcohol to obtain 1-nitro-2- (propynyloxymethyl) -benzene, then reducing by adopting iron powder/acetic acid or NiCl2 (dppp)/tetrahydroxy diboron/organic base to obtain 2- (propynyloxymethyl) -aniline, carrying out Sonogashira coupling with iodobenzene to obtain 2- [ (3-phenyl-2-alkynyloxy) methyl ] -aniline, carrying out benzoyl protection on amino, closing a ring by cuprous bromide/cesium carbonate, and then carrying out deprotection under an alkaline condition to obtain 2-benzyl-1, 5-dihydrobenzo [ e ] [1,4] oxazepine. |
| priorityDate | 2018-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 109.