http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108774173-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D225-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D225-02 |
| filingDate | 2018-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108774173-B |
| titleOfInvention | Synthesis method of E-type olefin eight-membered ring marker in bioorthogonal experiment |
| abstract | The invention relates to a method for synthesizing an E-type olefin eight-membered ring marker in a bioorthogonal experiment, which comprises the following steps: (a) dissolving the compound A in tetrahydrofuran, and cooling to be less than or equal to 0 ℃; then adding 3-butene-1-ol, triphenylphosphine and diethyl azodicarboxylate to carry out stirring reaction, concentrating and purifying by a column to obtain a compound II; (b) dissolving the compound II in dichloromethane, adding Grubbs 1 st The catalyst is stirred for reaction, and after concentration, the mixture is purified by a column to obtain a compound III; (c) adding the compound III into n-heptane, and then adding diethyl isophthalate and AgNO 3 /SiO 2 Adsorbent, reaction under 280nm UV lamp irradiation, and subsequent AgNO reaction 3 /SiO 2 Purifying by adsorption silica gel column chromatography. The synthesis of the E-type olefin eight-membered ring can be realized by adopting a specific synthetic route and only three steps, and the yield and the purity are high. |
| priorityDate | 2018-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.