http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108753837-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0375 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22 |
| filingDate | 2018-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108753837-B |
| titleOfInvention | Construction method of rabbit model with hyperlipidemia or atherosclerosis and sgRNA |
| abstract | The invention discloses a construction method of a rabbit model with hyperlipidemia or atherosclerosis and sgRNA. The construction method comprises the following steps: the 2 nd exon or/and the 7 th exon of the rabbit LDLR gene are targeted, and the partial sequence of the LDLR gene is deleted, so that the rabbit presents the phenotype of hyperlipidemia and atherosclerosis. The designed sgRNA guide sequence is shown AS SEQ ID No. 1-4, the invention edits specific sites of rabbit specific genes, can successfully obtain spontaneous hyperlipemia and atherosclerosis rabbits, provides a method for establishing a hyperlipemia and atherosclerosis rabbit model, and can be used for research on blood fat reducing efficacy, such AS screening and evaluation of similar drugs, discussion on AS etiology and pathogenesis, exploration of treatment strategies and research and development of prevention and treatment drugs. |
| priorityDate | 2018-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 124.