http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108752542-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F2438-01 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F293-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F293-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-34 |
| filingDate | 2018-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108752542-B |
| titleOfInvention | Amphiphilic block polymer with hypoxia and pH dual responsiveness and using azo bond as connecting bond and preparation method thereof |
| abstract | The invention belongs to the field of biological materials and nano materials, and relates to an amphiphilic block polymer which takes azo bonds as connecting bonds and has dual responsiveness of oxygen lack and pH and a preparation method thereof. The method comprises the following specific steps: the ring-opening polymerization copolymer of hydroxy azobenzene and cyclohexadene with one end esterified is used as an initiator to initiate atom transfer radical polymerization of N, N-diethylaminoethyl methacrylate monomer, and the amphiphilic block copolymerization material with azo bond as a connecting bond is obtained. The amphiphilic block copolymer material prepared by the invention has dual responsiveness of hypoxia and pH, can be self-assembled in aqueous solution to form nano micelle, and has wide application prospect in biomedical fields, such as construction of a targeted drug delivery system aiming at a microenvironment with hypoxia and micro-acid presented by tumor cells, diagnosis and treatment of ischemic diseases, hypoxic imaging in life bodies and the like. The method is simple and feasible, and the raw materials can be industrially produced, so the method has wide application prospect. |
| priorityDate | 2018-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.