http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108752404-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2018-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108752404-B |
| titleOfInvention | A kind of berberine salt derivative and its preparation method and application that triazole is sugar-modified |
| abstract | The invention discloses a kind of berberine salt derivatives and its preparation method and application that triazole is sugar-modified, belong to medicinal chemistry arts, after the sugar-modified berberine salt derivative of triazole of the invention enters in vivo, due to using triazole to connect glycosidic bond for linking group, into in vivo after be not easy to be digested by glycosidase, stability in vivo greatly improves, to increase the medicinal activity of berberine salt derivative, and it is readily soluble in water, various conventional galenic preparations are conveniently prepared into, are had a wide range of application；Berberine salt derivative of the invention connects carbohydrate moieties by triazole, on the one hand, improves the stability of berberine salt derivative, while having lower cytotoxicity；On the other hand, the presence of carbohydrate moieties can promote the combination of jamaicin and action target spot, improve its biocompatibility, compare existing berberine salt derivative, and antitumor, hypoglycemic and hypolipidemic activity, which has, to be significantly improved, and is substantially reduced to the toxicity of cell. |
| priorityDate | 2018-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.