| abstract |
The invention belongs to the technical field of medicine, and in particular relates to a spiro[indolezine-isoxazoline] derivative containing a pyrazole structure and a preparation method and application thereof. A preparation method of a spiro[indolezine-isoxazoline] derivative containing a pyrazole structure of the present invention comprises the following steps: (1) 3-methyl-1-phenyl-5-(1,2, Synthesis of 4-triazolyl)-4-pyrazole carboxyaldehyde; (2) 3-methyl-1-phenyl-5-(1,2,4-triazole-1-yl)-4-pyrazole Synthesis of formaldehyde oxime; (3) Synthesis of 3-methyl-1-phenyl-5-(1,2,4-triazole-1-yl)-α-chloro-4-pyrazole formaldehyde oxime; ( 4) Obtaining a spiro[indolezine-isoxazoline] derivative containing a pyrazole structure. |