http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108752328-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-10 |
| filingDate | 2018-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108752328-B |
| titleOfInvention | Simple method for synthesizing azilsartan |
| abstract | The invention relates to the field of medicine, and discloses a method for simply and conveniently synthesizing azilsartan, which comprises the steps of mixing 1- [ (2' - (hydroxycarbamimidoyl) [1, 1-biphenyl ] -4-yl) methyl ] -2-ethoxy-1H-benzimidazole-7-methyl formate with a carbonylation reagent, using water as a solvent, and reacting at 25 ℃ to obtain an O-acylated intermediate; mixing the O-acylated intermediate with an alkaline reagent, taking water as a solvent, carrying out reflux reaction at 100 ℃, filtering, adjusting the pH of the filtrate to 3-4 by using 1mol/L diluted HCl, carrying out suction filtration, and recrystallizing the solvent to obtain the azilsartan. The invention combines two steps of reaction of cyclization and hydrolysis into one step under the action of alkali, obtains the azilsartan in two steps in a water phase, reduces the synthesis steps, is simple and convenient to operate, takes water as a solvent, and has high industrial application value. |
| priorityDate | 2018-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.