http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108752316-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 |
| filingDate | 2018-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108752316-B |
| titleOfInvention | Tetrahydroisoquinoline-2-methylbenzimidazole salt compound and preparation method and application thereof |
| abstract | The invention provides a tetrahydroisoquinoline-2-methylbenzimidazole salt compound, belonging to the field of organic compounds. The invention designs and synthesizes a series of tetrahydroisoquinoline-2-methylbenzimidazole salt compounds based on two pharmacophores of tetrahydroisoquinoline and 2-methylbenzimidazole so as to research the biological activity of the compounds, thereby discovering new molecules with good anti-tumor activity and providing material basis and new guiding significance for further medicinal chemical research. The experimental data of the embodiment show that the tetrahydroisoquinoline-2-methylbenzimidazole salt compounds with the structure shown in the formula I have obvious in-vitro tumor growth inhibition activity on 5 human cancer cells (leukemia, liver cancer, lung cancer, breast cancer and colon cancer cells), and the in-vitro tumor growth inhibition activity of part of the compounds on A-549, MCF-7 and SW480 is superior to that of an anticancer drug cisplatin (DDP). |
| priorityDate | 2018-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.