| abstract |
The invention relates to a polynary nitrogen heterocyclic non-natural chiral amino acid and a synthesis method thereof, which can be applied to the molecular building blocks of synthesizing antibiotics and other medicines. By using 2-aminomalonate diethyl ester and halogenated alkanes for substitution, ring formation, decarboxylation, and then resolution, the multivariate nitrogen-heterocyclic non-natural chiral amino acid can be prepared. The new synthesis method of the invention has simple route, low cost, convenient operation and easy commercial production, and the obtained product has high chiral purity and has good application prospect. |