http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108752230-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 2018-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108752230-B |
| titleOfInvention | Synthesis method of key intermediate of contrast agent iodixanol impurity E |
| abstract | The invention discloses a synthesis method of a key intermediate of a contrast agent iodixanol impurity E, which takes 5-amino-N, N-bis (2, 3-dihydroxypropyl) -2,4, 6-triiodo-1, 3-benzenedicarboxamide as a raw material, takes water as a solvent, adds concentrated sulfuric acid, iodine and iodic acid, and reacts at a certain temperature; and cooling the reaction liquid, regulating the pH value, cooling, crystallizing, filtering, drying, further separating and purifying to obtain the high-purity target product 5-amino-N- (2, 3-dihydroxypropyl) -2,4, 6-triiodo-1, 3-benzenedicarboxamide. The iodic acid and iodine are added in the process to provide certain oxidizability and inhibit the deiodination reaction. And a small amount of concentrated sulfuric acid is added to provide an acidic environment and partial oxidation. In the preparation process of the compound III, the method of selecting and using the oxidant to react at high temperature under the acidic condition is simpler and more convenient compared with the method of introducing ammonia. |
| priorityDate | 2018-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.