http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108743958-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6929 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5123 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 |
| filingDate | 2018-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108743958-B |
| titleOfInvention | GSH response type mesoporous silicon nano drug-loaded particle with combined action of drug molecules and valve molecules and preparation method thereof |
| abstract | The invention provides GSH response type mesoporous silicon nano drug-carrying particles with combined action of drug molecules and valve molecules, which consist of mesoporous silicon nano particles with negative charge and hydrophobic short peptides grafted on the surfaces and drug molecules, wherein the drug molecules are hydrophobic drug molecules with positive charge and benzene ring structures, the surface of the mesoporous silicon nano particles with negative charge and hydrophobic short peptides is grafted on the surfaces, the negatively charged and hydrophobic short peptide is grafted on the surface of the mesoporous silicon nano-particle through a glutathione response type functional group, part of the drug molecules are positioned in the pore canal of the mesoporous silicon nano-particle with the negatively charged and hydrophobic short peptide grafted on the surface, part of the drug molecules are combined with the negatively charged and hydrophobic short peptide under the hydrophobic effect and the electrostatic effect to form a plugging valve, and the plugging valve plugs the orifice of the pore structure of the mesoporous silicon nano-particles with the negatively charged and hydrophobic short peptide grafted on the surface. |
| priorityDate | 2018-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.