http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108743603-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7056 |
| filingDate | 2018-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108743603-B |
| titleOfInvention | Antifungal product with ribavirin used alone or in combination with fluconazole and application thereof |
| abstract | The invention discloses an antifungal product of ribavirin used alone or in combination with fluconazole. The invention researches the antifungal effect of ribavirin used alone or in combination with fluconazole on candida albicans. When the ribavirin is used alone, the effective concentration is 2-8 mug/ml. When the ribavirin and the fluconazole are jointly applied, the antibacterial activity of the fluconazole on the drug-resistant candida albicans can be enhanced, a synergistic antifungal effect can be generated, the drug resistance of the drug-resistant candida albicans on triazole antifungal drugs can be reversed, and a research direction is provided for the development of new drugs and the new application of old drugs. The minimum inhibitory concentration of the drug-resistant candida albicans to fluconazole (MIC is more than 512 mu g/ml) can be obviously reduced by combined administration, more than 80% of fungi can be killed by the combined application of 1 mu g/ml ribavirin and 0.25-1 mu g/ml fluconazole, the concentration is increased again, and the effect is stronger. |
| priorityDate | 2018-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 140.