http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108728496-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0041 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G83-004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G83-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87 |
| filingDate | 2018-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108728496-B |
| titleOfInvention | Polycation gene vector, preparation method and application thereof |
| abstract | The invention provides a polycation gene vector, a preparation method and application thereof, wherein the polycation gene vector comprises a grafting framework and arginine protected by tosyl grafted with the grafting framework; the raw material of the grafting framework is selected from dendritic polyamide-amine, hyperbranched polylysine with molecular weight of 2000-100000 g/mol or linear epsilon-polylysine with molecular weight of 2000-50000 g/mol; the dendritic polyamidoamine is selected from one or more of model PAMAM-G3, model PAMAM-G4 and model PAMAM-G5. The polycation gene vector provided by the invention grafts the arginine protected by the tosyl on a specific grafting framework, and can obviously improve the transfection efficiency of the compound nanoparticles prepared by the polycation vector. In addition, the charge density of the nano-composite particles can be effectively reduced, and the cytotoxicity of the nano-composite particles is further reduced. |
| priorityDate | 2018-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.