abstract |
The present invention provides a long-acting nerve growth factor, which comprises a first polypeptide having an N-terminus and a C-terminus fused to a second polypeptide having an N-terminus and a C-terminus, characterized in that: the first polypeptide It is a nerve growth factor, and the long-acting nerve growth factor obtained after the C-terminus of the first polypeptide is fused with the N-terminus of the second polypeptide, the long-acting nerve growth factor has an in vivo half-life of more than 14 hours, and its biological activity is relatively high. |