http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108727467-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3a5f87a35a4ce443391ef57e6ff46d3a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0202 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06017 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-023 |
| filingDate | 2018-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db3bb762d45398bac6f5c1bd8b112180 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e19ed741c27db06612d23bfcd0bebba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8757f49e0c0ab7e35b93c58aba76bb78 |
| publicationDate | 2018-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108727467-A |
| titleOfInvention | A class of bisacyloxytetrapeptide drug intermediates and preparation method thereof |
| abstract | The invention provides a class of bisacyloxy tetrapeptide drug intermediates. The general formula is as follows (I) ( 1 ), R in the formula is methyl, ethyl, isopropyl, isooctyl, n - heptyl, R is chlorine, bromine, methyl, isooctyl, n-heptyl, R is hydrogen or Chlorine, R4 is alkyl such as methyl, ethyl, isopropyl, n - hexyl, aryl or heteroaryl such as phenyl, substituted phenyl, R5 is methyl, ethyl, isopropyl, n - hexyl Equal alkyl, aryl or heteroaryl such as phenyl, substituted phenyl, R6 is alkyl such as methyl, ethyl, isopropyl, n - hexyl, aryl or heteroaryl such as phenyl, substituted phenyl . Its preparation method is to add acid chloride into a flask equipped with hydroxytetrapeptide, then add diisopropylethylamine, the reaction solvent is dichloromethane, and react for 1-5 hours. After the reaction is completed, remove it under reduced pressure. Solvent dichloromethane, residue column chromatography to obtain the target compound of general formula (I). Such drug intermediates can be further used to synthesize bioactive peptide drugs. |
| priorityDate | 2018-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.