| abstract |
The present invention relates to novel benzodiazepines with antiproliferative activity Derivatives, more specifically, to novel benzodiazepines of formula (I) and (II) Among them, the diazepine Ring (B) is fused to a heterocycle (CD), wherein said heterocycle is bicyclic or relates to a compound of formula (III), wherein said diazepine Ring (B) is fused to a heterocycle (C), wherein the heterocycle is monocyclic. The present invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of monomers and dimers. The invention further provides compositions for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal and methods of using the compounds or conjugates of the invention useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ and in vivo diagnosis or treatment of mammalian cells or associated pathological conditions. |