http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108727230-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-73 |
| filingDate | 2017-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108727230-B |
| titleOfInvention | Ibrutinib intermediate and preparation method thereof |
| abstract | The invention discloses an ibrutinib intermediate and a preparation method thereof. The structure of the ibrutinib intermediate is shown in a formula I, and the definition of R is shown in the specification and the claims. The ibrutinib intermediate can be used for preparing an ibrutinib key intermediate 3- (4-phenoxyphenyl) -1H-pyrazolo [3,4-d]A pyrimidin-4-amine comprising the steps of: preparing an active intermediate compound shown in formula II from the compound shown in formula I under the action of an active nucleophilic reagent; cyclizing the compound shown in the formula II to obtain a compound shown in the formula 4, namely 3-amino-5- (4-phenoxyphenyl) -4-cyano-1H-pyrazole; the compound of the formula 4 is subjected to ring closure to obtain an ibrutinib key intermediate. The method has the advantages of cheap and easily obtained raw materials, no need of hazardous reagents, mild reaction conditions, simple operation and suitability for industrial production. |
| priorityDate | 2017-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 119.