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filingDate 2018-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1129f86cf95520819fc6ad691914f072
publicationDate 2018-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-108721348-A
titleOfInvention A kind of asiaticoside liposome and preparation method thereof
abstract A kind of asiaticoside liposome of present invention proposition and preparation method thereof, belongs to drug and medicine manufacture technology field.Asiaticoside fat limbs include lecithin, cholesterol, asiaticoside and ultra-pure water, and the mass ratio of lecithin and cholesterol is 4-8 ﹕ 1;The mass ratio of lecithin and asiaticoside is 20-40:1;The volume ratio of organic phase and water phase is 5-7 ﹕ 1.Method:Lecithin, cholesterol are weighed by a certain percentage, and lecithin, cholesterol are dissolved in chloroform;The aqueous solution of asiaticoside is added, ice-water bath ultrasound forms uniform emulsion;By emulsion rotary evaporation to gel state is formed, appropriate ultra-pure water solution is added;Continuing revolving makes colloid fall off in 1 hour, and ice-water bath ultrasound is up to liposome beneficial effects of the present invention:The present invention have good percutaneous abilities and slow release effect, can be permanently effective act on lesion, realize better therapeutic effect.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115068352-B
priorityDate 2018-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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