http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108714220-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6817 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 |
| filingDate | 2018-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108714220-B |
| titleOfInvention | Cysteine engineered antibody-toxin conjugates |
| abstract | Modifying serine (S) at position 235 of a heavy chain and valine (V) at position 205 of a light chain of a target antibody into cysteine (C), and performing site-specific coupling on a mc-vc-PAB-OH linker coupled with small-molecule high-activity cytotoxin (Payload) through free sulfydryl (-SH) of the modified cysteine to form a cysteine modified antibody-toxin conjugate with excellent uniformity, wherein the toxin-to-antibody ratio (DAR) of the cysteine modified antibody-toxin conjugate is 3.2-4.0, and the antibody-toxin conjugate has the general formula: 1C7-HC-S235C-LC-V205C-mc-vc-PAB-payload, and the invention also discloses a preparation and purification method of the TDC drug, and the application of the TDC drug in the treatment of tumors which over-express EGFRwt. |
| priorityDate | 2018-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 449.