http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108707625-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15021 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867 |
| filingDate | 2018-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108707625-B |
| titleOfInvention | mir-124 and HER2-shRNA double-gene expression cassette virus vector, construction method, virus and application |
| abstract | The invention relates to the technical field of molecular biology, in particular to a mir124 and HER2-shRNA double-gene expression cassette virus vector, a construction method, a virus and application. The double-gene expression box virus vector is constructed by integrating and connecting a mir-124 sequence and a HER2-shRNA sequence in a virus expression vector; wherein the mir-124 sequence is shown as SEQ ID NO.1, and the HER2-shRNA sequence is shown as SEQ ID NO.2 and SEQ ID NO. 3. The transfection rate of the gene expression vector for the breast cancer cell reaches 80-90%, mir-124 and HER2-shRNA can be efficiently and stably expressed in the breast cancer cell, the synergistic effect is exerted, the proliferation of the breast cancer cell can be remarkably inhibited, the apoptosis is promoted, and the gene expression vector can be used for gene therapy of HER2 positive tumors such as breast cancer, ovarian cancer and the like. |
| priorityDate | 2018-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.